Report Delivery
4 Days
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Free Sample Collection
Bookings above 500
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Pre - Instruction
No Preparation Required.
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Covid Safety
Assured
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Test Details |
Test Code |
BOBT00550 |
Test Category |
Individual Test |
Sample Type |
Blood |
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Details of ANTI SCL-70
What is ANTI SCL-70 ?
Evaluating patients with signs and symptoms of scleroderma and other connective tissue diseases in whom the test for antinuclear antibodies is positive
Testing for Scl 70 antibodies is not useful in patients without demonstrable antinuclear antibodies.
Testing Algorithm
See Connective Tissue Disease Cascade (CTDC) in Special Instructions.
Clinical Information
Scl 70 (topoisomerase 1) is a 100-kD nuclear and nucleolar enzyme. Scl 70 antibodies are considered to be specific for scleroderma (systemic sclerosis) and are found in up to 60% of patients with this connective tissue disease. Scl 70 antibodies are more common in patients with extensive cutaneous involvement and interstitial pulmonary fibrosis, and are considered a poor prognostic sign.