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AQUAPORIN-4 (NMO) Antibody
Parameters : 1
Also known as : AQUAPORIN-4 (NMO) Antibody
EXCLUSIVE PRICE
4500
Report Delivery
7 Days
Free Sample Collection
Bookings above 500
Pre - Instruction
No special preparation required
Covid Safety
Assured
Test Details
Test Code BOBT00206
Test Category Individual Test
Sample Type Blood
Details of AQUAPORIN-4 (NMO) Antibody
What is AQUAPORIN-4 (NMO) Antibody?
Aquaporin 4 (AQP4) is a water channel protein found on cells known as astrocytes that surround the blood-brain barrier, (a layer of cells responsible for preventing dangerous substances in the blood from crossing into the brain). It is presumed that the blood-brain barrier allows the AQP4 antibodies to enter the central nervous system. This causes inflammation and demyelination and symptoms of a relapse.

Approximately 80% of people diagnosed with NMOSD have Aquaporin 4 antibodies in their blood.
When to test for AQP4 Antibodies
  • If a patient has recurrent, bilateral or severe optic neuritis
  • If a patient has longitudinal, or recurrent transverse myelitis
  • If lumbar MRI spine shows a lesion greater than 3 vertebrae
  • If a patient has poor recovery from MS relapses
If the test is positive, please refer the patient to one of the centers.
However 20% of people with NMOSD do not have Aquaporin 4 antibodies, If you have any concerns regarding diagnosis or management, please refer to the NMO service.
Useful For
  • Diagnosis of a neuromyelitis Optica spectrum disorder (NMOSD)
  • Diagnosis of autoimmune AQP4 channelopathy
  • Diagnosis of neuromyelitis Optica (NMO)
  • Distinguishing NMOSD from multiple sclerosis early in the course of the disease
Testing Algorithm
When the results of this assay require further evaluation, NMOTS / Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Titer Assay, Serum will be performed at an additional charge.
Method Name
Flow Cytometry
Aliases
  • AQP
  • AQP4
  • Aquaporin
  • Devic's Antibody
  • NMO (Neruomyelitis Optica)
  • NMO-IgG
  • Optic Neuritis Antibody
  • Transverse Myelitis Antibody
  • Vision Loss Antibody
Routine Tests
AQUAPORIN-4 (NMO) Antibody
Parameters : 1
Also known as : AQUAPORIN-4 (NMO) Antibody
EXCLUSIVE PRICE
4500
Report Delivery
7 Days
Free Sample Collection
Bookings above 500
Pre - Instruction
No special preparation required
Covid Safety
Assured
Test Details
Test Code BOBT00206
Test Category Individual Test
Sample Type Blood
Details of AQUAPORIN-4 (NMO) Antibody
What is AQUAPORIN-4 (NMO) Antibody?
Aquaporin 4 (AQP4) is a water channel protein found on cells known as astrocytes that surround the blood-brain barrier, (a layer of cells responsible for preventing dangerous substances in the blood from crossing into the brain). It is presumed that the blood-brain barrier allows the AQP4 antibodies to enter the central nervous system. This causes inflammation and demyelination and symptoms of a relapse.

Approximately 80% of people diagnosed with NMOSD have Aquaporin 4 antibodies in their blood.
When to test for AQP4 Antibodies
  • If a patient has recurrent, bilateral or severe optic neuritis
  • If a patient has longitudinal, or recurrent transverse myelitis
  • If lumbar MRI spine shows a lesion greater than 3 vertebrae
  • If a patient has poor recovery from MS relapses
If the test is positive, please refer the patient to one of the centers.
However 20% of people with NMOSD do not have Aquaporin 4 antibodies, If you have any concerns regarding diagnosis or management, please refer to the NMO service.
Useful For
  • Diagnosis of a neuromyelitis Optica spectrum disorder (NMOSD)
  • Diagnosis of autoimmune AQP4 channelopathy
  • Diagnosis of neuromyelitis Optica (NMO)
  • Distinguishing NMOSD from multiple sclerosis early in the course of the disease
Testing Algorithm
When the results of this assay require further evaluation, NMOTS / Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Titer Assay, Serum will be performed at an additional charge.
Method Name
Flow Cytometry
Aliases
  • AQP
  • AQP4
  • Aquaporin
  • Devic's Antibody
  • NMO (Neruomyelitis Optica)
  • NMO-IgG
  • Optic Neuritis Antibody
  • Transverse Myelitis Antibody
  • Vision Loss Antibody
 

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