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Anti phospholipase A2 Receptor (PLA 2R) IGG
Parameters : 1
Also known as : Anti phospholipase A2 Receptor (PLA 2R) IGG
EXCLUSIVE PRICE
7500
Report Delivery
12 Days
Free Sample Collection
Bookings above 500
Pre - Instruction
No Preparation Required.
Covid Safety
Assured
Test Details
Test Code BOBT00823
Test Category Individual Test
Sample Type Blood
Details of Anti phospholipase A2 Receptor (PLA 2R) IGG
What is Anti phospholipase A2 Receptor (PLA 2R) IGG?
Anti-phospholipase A2 receptor (PLA2R) antibodies are highly specific for the diagnosis of primary membranous nephropathy.
As many as 70% to 75% of patients with primary membranous nephropathy are positive for anti-PLA2R.
A titer increase, decrease, or disappearance generally precedes a change in clinical status.
CLINICAL INFORMATION
Membranous nephropathy (MN) is a rare disease in which immune complexes deposit at the glomerular basement membrane, causing damage to the filtration barrier, and resulting in proteinuria. Recent studies have shown that in approximately 70% of patients with primary MN (pMN), the immune complexes consist of autoantibodies against the podocyte protein M-type phospholipase A2 receptor (PLA2R). There is also evidence that levels of anti-PLA2R autoantibodies correlate well with disease activity and progression. The presence of anti-PLA2R antibodies could also potentially be used to differentiate pMN from other causes of the nephrotic syndrome if a biopsy is not possible. Among patients with chronic kidney disease (CKD) awaiting kidney transplantation, higher levels of anti-PLA2R could predict those more likely to recur after transplantation.
Routine Tests
Anti phospholipase A2 Receptor (PLA 2R) IGG
Parameters : 1
Also known as : Anti phospholipase A2 Receptor (PLA 2R) IGG
EXCLUSIVE PRICE
7500
Report Delivery
12 Days
Free Sample Collection
Bookings above 500
Pre - Instruction
No Preparation Required.
Covid Safety
Assured
Test Details
Test Code BOBT00823
Test Category Individual Test
Sample Type Blood
Details of Anti phospholipase A2 Receptor (PLA 2R) IGG
What is Anti phospholipase A2 Receptor (PLA 2R) IGG?
Anti-phospholipase A2 receptor (PLA2R) antibodies are highly specific for the diagnosis of primary membranous nephropathy.
As many as 70% to 75% of patients with primary membranous nephropathy are positive for anti-PLA2R.
A titer increase, decrease, or disappearance generally precedes a change in clinical status.
CLINICAL INFORMATION
Membranous nephropathy (MN) is a rare disease in which immune complexes deposit at the glomerular basement membrane, causing damage to the filtration barrier, and resulting in proteinuria. Recent studies have shown that in approximately 70% of patients with primary MN (pMN), the immune complexes consist of autoantibodies against the podocyte protein M-type phospholipase A2 receptor (PLA2R). There is also evidence that levels of anti-PLA2R autoantibodies correlate well with disease activity and progression. The presence of anti-PLA2R antibodies could also potentially be used to differentiate pMN from other causes of the nephrotic syndrome if a biopsy is not possible. Among patients with chronic kidney disease (CKD) awaiting kidney transplantation, higher levels of anti-PLA2R could predict those more likely to recur after transplantation.
 

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