What is TYPHIDOT - IGG?

As typhoid fever is endemic in India, there is a continuing search for a simple test that can be carried out in small laboratories for an early and rapid diagnosis. We have evaluated the Typhidot test for this purpose.

Methods: The Typhidot test was carried out on coded sera according to the manufacturer's instructions. The test was performed on 30 Widal positive sera, 30 sera from blood culture-positive patients, 60 Widal negative sera, and 30 samples from patients whose blood culture grew Gram-negative bacilli (GNB) other than Salmonella Typhi.

Results: Typhidot test was positive for both IgG and IgM in 39 samples, IgM alone in 24 and IgG alone in 2. Of the 30 culture-positive samples, 27 were positive by Typhidot. The Typhidot test gave a sensitivity of 100 percent and specificity of 80 percent when bacteremia patients were analyzed.

Interpretation & conclusion: The Typhidot is easy to perform and requires no special equipment or training of staff for interpretation of results. It will be a useful complementary test to blood culture and the Widal test in the diagnosis of typhoid fever.